منابع مشابه
DNA methylation in mammals.
DNA methylation is one of the best characterized epigenetic modifications. In mammals it is involved in various biological processes including the silencing of transposable elements, regulation of gene expression, genomic imprinting, and X-chromosome inactivation. This article describes how DNA methylation serves as a cellular memory system and how it is dynamically regulated through the action...
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متن کاملThe DNA methyltransferases of mammals.
The biological significance of 5-methylcytosine was in doubt for many years, but is no longer. Through targeted mutagenesis in mice it has been learnt that every protein shown by biochemical tests to be involved in the establishment, maintenance or interpretation of genomic methylation patterns is encoded by an essential gene. A human genetic disorder (ICF syndrome) has recently been shown to b...
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We report the formation and characterisation of easily functionalisable mixed micelles with DNA/PEO corona and PPO core which can be loaded with hydrophobic molecules and stabilised by the formation of a cross-linked semi-interpenetrating network. Furthermore, the corona is functionalised by hybridisation either with dye-modified complementary DNA, with demonstrable distance control, or with DN...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2004
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20041025-01